HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 22224811, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzoyl chloride, 3-nitro- | HCID 8495 | — |
| Reactant | Trifluoroacetic anhydride | HCID 9845 | — |
| Reactant | Magnesium Chloride | HCID 5360315 | — |
| Reactant | HCID 23662309 | HCID 23662309 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | TFA acetone | HCID 86586799 | — |
| Product | HCID 22224811 | HCID 22224811 | — |
| Product | HCID 69593002 | HCID 69593002 | — |
Reaction Steps
The 3-(3-nitro-phenyl)-3-oxo-propionic acid tert.-butyl ester was prepared from 3-nitrobenzoyl chloride (2.71 g, 14.6 mmol) and tert.-butyl malonate potassium salt (6.0 g, 30.0 mmol) with Et3N (4.5 mL, 32.2 mmol) and MgCl2 (3.48 g, 36.52 mmol) in CH3CN according to general procedure H (method a). The crude material (3.88 g) was transformed into the title compound by stirring in TFA/acetone with TFAA according to general procedure J (method b). Obtained as a yellow solid (2.76 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07018998B2 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-a05add1a4341446fbf2d6c06b5ff3e75 |
| Source note | uspto-grants-2006_03 |