HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(3-Chloro-phenyl)-2,2-dimethyl-[1,3]dioxin-4-one → {4-Benzoyl-2-[3-(3-chloro-phenyl)-3-oxo-propionylamino]-phenyl}-carbamic acid tert.-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(3-Chloro-phenyl)-2,2-dimethyl-[1,3]dioxin-4-one | HCID 22224690 | — |
| Reactant | Carbamic acid,(2-amino-4-benzoylphenyl)-,1,1-dimethylethyl ester | HCID 69592848 | — |
| Product | {4-Benzoyl-2-[3-(3-chloro-phenyl)-3-oxo-propionylamino]-phenyl}-carbamic acid tert.-butyl ester | HCID 86588006 | 71.3% |
Reaction Steps
Prepared from (2-amino-4-benzoyl-phenyl)-carbamic acid tert.-butyl ester (Example G24) (205 mg, 0.66 mmol) and 6-(3-chloro-phenyl)-2,2-dimethyl-[1,3]dioxin-4-one (Example J6) (174 mg, 0.73 mmol) according to the general procedure K. Obtained as a brown foam (232 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07018998B2 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-3e09866b8818457faf2d12c0eccbc9ac |
| Source note | uspto-grants-2006_03 |