HRID1745604

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC1(C)OC(=O)C=C(c2ccnc(-n3ccnc3)c2)O1

HCID22224862

未命名化合物

结构：CC(C)(C)OC(=O)Nc1ccc(-c2ccc(F)cc2)cc1N

HCID59737201

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)Nc1ccc(-c2ccc(F)cc2)cc1NC(=O)CC(=O)c1ccnc(-n2ccnc2)c1

HCID86588030

未命名化合物

PROCEDURE

实验过程

Prepared from (3-amino-4′-fluoro-biphenyl-4-yl)-carbamic acid tert.-butyl ester (Example G39) and 6-(2-imidazol-1-yl-pyridin-4-yl)-2,2-dimethyl-[1,3]dioxin-4-one (Example J14) according to the general procedure K. Obtained as a brown solid (361 mg).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1f40f6ffaa6e4e328fdc5f0b7fd07ce2
来源数据集: uspto-grants-2006_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07018998B2
来源说明: uspto-grants-2006_03

反应 SMILES

[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)=[CH:10][C:9]=1[NH2:21])([CH3:4])([CH3:3])[CH3:2].[N:23]1([C:28]2[CH:33]=[C:32]([C:34]3[O:39]C(C)(C)[O:37][C:36](=O)[CH:35]=3)[CH:31]=[CH:30][N:29]=2)[CH:27]=[CH:26][N:25]=[CH:24]1>>[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:15]=[CH:16][C:17]([F:20])=[CH:18][CH:19]=2)=[CH:10][C:9]=1[NH:21][C:36](=[O:37])[CH2:35][C:34]([C:32]1[CH:31]=[CH:30][N:29]=[C:28]([N:23]2[CH:27]=[CH:26][N:25]=[CH:24]2)[CH:33]=1)=[O:39])([CH3:4])([CH3:2])[CH3:3]