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HRID1745734

反应详情

EQUATION

反应方程式

HRID 1745734 的结构方程式

REACTANTS

反应物

3
结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：CC1(C)OC(=O)C=C(c2cccc(C#N)c2)O1
HCID11736337

未命名化合物

结构：COc1cccc(F)c1-c1ccc(NC(=O)OC(C)(C)C)c(N)c1
HCID69592800

未命名化合物

PRODUCTS

生成物

1
结构：COc1cccc(F)c1-c1ccc2c(c1)NC(=O)CC(c1cccc(C#N)c1)=N2
HCID22224941

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Prepared from (3-amino-2′-fluoro-6′-methoxy-biphenyl-4-yl)-carbamic acid tert.-butyl ester (Example G44) and 3-(2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrile (Example J4) according to the general procedure K. The obtained material was deprotected and cyclized by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a white solid (47 mg).