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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1745772Generated: October 30, 2026

Trifluoroacetic acid → 3-[7-(2-Fluoro-phenylethynyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl]-benzonitrile

https://huagongshe.com/reaction/1745772

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactant[2-[3-(3-Cyano-phenyl)-3-oxo-propionylamino]-4-(2-fluoro-phenylethynyl)-phenyl]-carbamic acid tert.-butyl esterHCID 86588081—
SolventDichloromethaneHCID 6344—
Product3-[7-(2-Fluoro-phenylethynyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl]-benzonitrileHCID 22224615—

Reaction Steps

Prepared from [2-[3-(3-cyano-phenyl)-3-oxo-propionylamino]-4-(2-fluoro-phenylethynyl)-phenyl]-carbamic acid tert.-butyl ester (Example K97) by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a yellow solid (82 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07018998B2
Source datasetuspto-grants-2006_03
ORD IDord-71e7a015bee24a53bfcdf94381adc166
Source noteuspto-grants-2006_03