(Trifluoromethyl)benzene → Cyclododecanone

Participants

Reaction Steps

To 9 ml of trifluorotoluene was added 504 mg (3.0 mmol) of cyclododecane, 60 mg (0.3 (mmol) of N-hydroxysaccharin and 5.3 mg (0.015 mmol) of acetylacetonatocobalt Co(acac)3. The resultant mixture was stirred under an oxygen atmosphere at a temperature of 100° C. for 4 hours. The products in the reaction mixture were analysed by gas chromatography, with cyclododecane being transformed, with a conversion of 34.5%, into cyclododecanone (selectivity 64%, yield 22%), cyclododecanol (selectivity 16.5%, yield 5.5%) and dodecanediacid (selectivity 5%, yield 2%).

Provenance & Evidence