Acetic Acid → Cyclooctanone

Participants

Reaction Steps

To 27.5 ml of acetic acid were added to 336 mg (3.0 mmol) of cyclooctane, 60 mg (0.3 mmol) of N-hydroxysaccharin and 3.7 mg (0.015 mmol) of Co(OAc)2.4H2O. The resultant mixture was stirred under an oxygen atmosphere at a temperature of 50° C. for 9 hours. The products in the reaction mixture were analysed by gas chromatography, with cyclooctane being transformed, with a conversion of 43.5%, into cyclooctanone (selectivity 43.5%, yield 19%), cyclooctanol (selectivity 18%, yield 8%), 1,4-cyclooctanedione (selectivity 4.5%, yield 2%) and octanediacid (selectivity 23%, yield 10%).

Provenance & Evidence