Sodium Bicarbonate → HCID 86759956, compound

Participants

Reaction Steps

Trifluoro-methanesulfonic acid 2-[5-(2-methoxy-ethoxy]benzoimidazol-1-yl]-quinolin-8-yl ester 77E (2.00 g, 4.28 mMol) was suspended in 20 mL of anydrous DCM under an atmosphere of dry N2. To this heterogeneous solution was added 12.9 mL of a solution of 1 M borontribromide in DCM and the resulting mixture was stirred at ambient temperature for 24 hours. The reaction mixture was then poured into ice water. The resulting heterogeneous mixture was neutralised with the addition of NaHCO3 and then partitioned between isopropanol/DCM (1882) and aqueous saturated NaHCO3. The organic layer was washed again aqueous saturated NaHCO3, dried over Na2SO4, filtered, concentrated under vacuum to give 890 mg of a brownish yellow solid as the title compound 116A.

Provenance & Evidence