Tranylcypromine hydrochloride → (1R,2S)-Tranylcypromine

HRID 1746082Notes

Reaction equation

HRID 1746082 reaction equation
C[O-].[Na+].Cl.[C:5]1([C@@H:11]2[CH2:13][C@H:12]2[NH2:14])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>CO>[C:5]1([C@@H:11]2[CH2:13][C@H:12]2[NH2:14])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 2723716Tranylcypromine hydrochlorideHCID 10942334Sodium Methoxide

Product 1

HCID 19493(1R,2S)-Tranylcypromine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

NaOMe (0.80 g, 11.8 mmol) was added over a solution of (trans)-2-phenylcyclopropanamine hydrochloride (2.00 g, 11.8 mmol) in MeOH (40 mL) and stirred 1 hour. The solvent was removed to dryness.

Workup

  1. customThe solvent was removed to dryness

Sources & evidence

ORD record
ord-85986e9e902f4e05b97c138d51084269
Source dataset
uspto-grants-2015_10
Patent number
US09149447B2

Reaction notes

Loading…