2-Chloro-6-fluorobenzoic acid → 2-Chloro-N-[1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-4-yl]-6-fluorobenzamide

Participants

Role	Name	HCID	Charge
Reactant	2-Chloro-6-fluorobenzoic acid	HCID 67947	—
Reactant	1-({5-Chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-4-amine	HCID 67513476	—
Product	2-Chloro-N-[1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-4-yl]-6-fluorobenzamide	HCID 56967535	—

Reaction Steps

The title compound was prepared in a similar fashion to the preparation of example 16, replacing 1-[(2,4-dichlorophenyl)methyl]-1H-pyrazol-4-amine with 1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-4-amine (for a preparation see intermediate 9) and replacing 2,6-dichlorobenzoic acid with 2-chloro-6-fluorobenzoic acid (Aldrich); LCMS (System 3): MH+=470, tRET=1.28 min.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09149462B2
Source dataset	uspto-grants-2015_10
ORD ID	ord-d327c70a838940f8847757dab63a700e
Source note	uspto-grants-2015_10