6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)furo[3,2-b]pyridine → HCID 86650563, compound

HRID 1746123Notes

Reaction equation

HRID 1746123 reaction equation
[O:1]1[C:9]2[C:4](=[N:5][CH:6]=[C:7]([OH:10])[CH:8]=2)[CH:3]=[CH:2]1.CC1(C)C(C)(C)OB(C2C=C3[O:27][CH:26]=[CH:25][C:22]3=[N:23]C=2)O1>>[O:27]1[CH2:26][CH2:25][C:22]([O:10][C:7]2[CH:8]=[C:9]3[O:1][CH:2]=[CH:3][C:4]3=[N:5][CH:6]=2)=[N:23]1

Participants

3

Reactant 2

HCID 467368926-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)furo[3,2-b]pyridineHCID 46737910Furo[3,2-b]pyridin-6-ol2×

Product 1

HCID 86650563HCID 86650563, compound

Procedure

6-(4,5-dihydroisoxazol-3-yloxy)furo[3,2-b]pyridine I-69a and I-69b were prepared in 2 steps from racemic compound I-10 and furo[3,2-b]pyridin-6-ol using Method 5 after furo[3,2-b]pyridin-6-ol is prepared from 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)furo[3,2-b]pyridine using Method 11. These compounds can be separated using chiral HPLC methods known in the art. For example, see chiral HPLC Method disclosed herein. [M+H]+=374.2 m/z. Activity: A

Workup

  1. customThese compounds can be separated

Sources & evidence

ORD record
ord-d20e780e2e734cac84b2df1ce294c29d
Source dataset
uspto-grants-2015_10
Patent number
US09149465B2

Reaction notes

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