化工社化工社 化学情報印刷レポート · 研究参考用
4-Butoxybenzaldehyde → 3-(Pyridin-3-yloxy)-4,5-dihydroisoxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Butoxybenzaldehyde | HCID 79813 | — |
| 反応物 | Methyl 5-hydroxypyridine-2-carboxylate | HCID 4715126 | — |
| 反応物 | 3-Bromo-4,5-dihydroisoxazole | HCID 21983498 | — |
| 生成物 | 3-(Pyridin-3-yloxy)-4,5-dihydroisoxazole | HCID 66818532 | — |
反応手順
3-(pyridin-3-yloxy)-4,5-dihydroisoxazole I-137a and I-137b were prepared in 3 steps from 4-butoxybenzaldehyde using Method 8 followed by cycloaddition using Method 1. The resulting bromo-4,5-dihydroisoxazole was reacted with 5-hydroxypicolinic acid methyl ester using Method 5. These compounds can be separated using chiral HPLC methods known in the art. For example, see chiral HPLC Method disclosed herein. [M+H]+=370.1 m/z. Activity: A
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09149465B2 |
| 出典データセット | uspto-grants-2015_10 |
| ORD ID | ord-068d70c0d6b74d9082d212cf6828b542 |
| 出典メモ | uspto-grants-2015_10 |