4-Isopropoxybenzaldehyde → 3-(Pyrimidin-5-yloxy)-4,5-dihydroisoxazole

Beteiligte Stoffe

Reaktionsschritte

3-(pyrimidin-5-yloxy)-4,5-dihydroisoxazole I-141a and I-141b were prepared in 3 steps from 4-iso-propoxybenzaldehyde using Method 8 followed by cycloaddition using Method 1. The resulting bromo-4,5-dihydroisoxazole was reacted with 5-hydroxypyrimidine using Method 5. These compounds can be separated using chiral HPLC methods known in the art. For example, see chiral HPLC Method disclosed herein. [M+H]+=299.3 m/z. Activity: A

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