Pyrimidin-5-ol → 3-(Pyrimidin-5-yloxy)-4,5-dihydroisoxazole

HRID 1746132Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1746132
FC(F)(F)C1C=CC(C=C)=CC=1.Br[C:14]1[CH2:18][CH2:17][O:16][N:15]=1.[OH:19][C:20]1[CH:21]=[N:22][CH:23]=[N:24][CH:25]=1>>[N:22]1[CH:21]=[C:20]([O:19][C:14]2[CH2:18][CH2:17][O:16][N:15]=2)[CH:25]=[N:24][CH:23]=1

Komponenten

4

Edukt 3

HCID 565855Pyrimidin-5-olHCID 27827981-Ethenyl-4-(trifluoromethyl)benzeneHCID 219834983-Bromo-4,5-dihydroisoxazole

Produkt 1

HCID 866505643-(Pyrimidin-5-yloxy)-4,5-dihydroisoxazole

Versuchsvorschrift

3-(pyrimidin-5-yloxy)-4,5-dihydroisoxazole I-168a and I-168b were prepared in 2 steps from 1-(trifluoromethyl)-4-vinylbenzene using the cycloaddition conditions from Method 1. The resulting bromo-4,5-dihydroisoxazole was reacted with 5-hydroxypyrimidine to provide racemic compound I-168 using Method 5. These compounds can be separated using chiral HPLC methods known in the art. For example, see chiral HPLC Method disclosed herein. [M+H]+=309.8 m/z. Activity: B

Aufarbeitung

  1. customto provide racemic compound
  2. customThese compounds can be separated

Quellen und Nachweise

ORD-Eintrag
ord-670a09d29aae4cbb9fcc16f0c8604760
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09149465B2

Notizen zur Reaktion

Wird geladen…