Methyl 5-hydroxypyridine-2-carboxylate → 3-(Pyridin-3-yloxy)-4,5-dihydroisoxazole

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Reaction Steps

3-(pyridin-3-yloxy)-4,5-dihydroisoxazole I-215a and I-215b were prepared in 2 steps compound from racemic compound I-21. Bromo-4,5-dihydroisoxazole I-21 was reacted with 5-hydroxy picolinic acid methyl ester using Method 5 followed by hydrolysis using the analogous conditions as in example 94. These compounds can be separated using chiral HPLC methods known in the art. For example, see chiral HPLC Method disclosed herein. [M+H]+=418.3 m/z. Activity: B

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