3-Pyridinylboronic acid → HCID 178498931, compound

HRID 1746196Notes

Reaction equation

HRID 1746196 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:6](=[O:17])[S:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[C:10](Br)[CH:9]=2)=[O:4].[N:18]1[CH:23]=[CH:22][CH:21]=[C:20](B(O)O)[CH:19]=1>>[CH3:1][O:2][C:3]([C:5]1[C:6](=[O:17])[S:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[C:10]([C:20]1[CH:19]=[N:18][CH:23]=[CH:22][CH:21]=1)[CH:9]=2)=[O:4]

Participants

3

Reactant 2

HCID 27343783-Pyridinylboronic acidHCID 178498916HCID 178498916, compound

Product 1

HCID 178498931HCID 178498931, compound

Procedure

4-Hydroxy-2-oxo-7-pyridin-3-yl-2H-thiochromene-3-carboxylic acid methyl ester was prepared from 7-bromo-4-hydroxy-2-oxo-2H-thiochromene-3-carboxylic acid methyl ester (Example 5 e) and 3-pyridyl-boronic acid under conditions analogous to Example 14(a). MS ESI(+) m/e: 314.12 (M+1).

Sources & evidence

ORD record
ord-6c43c205548e4519a4759b20f91a5eac
Source dataset
uspto-grants-2015_10
Patent number
US09149476B2

Reaction notes

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