3-Fluorophenylboronic acid → HCID 178498923, compound

HRID 1746213Notes

Reaction equation

HRID 1746213 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:6](=[O:17])[S:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[C:10](Br)[CH:9]=2)=[O:4].[F:18][C:19]1[CH:20]=[C:21](B(O)O)[CH:22]=[CH:23][CH:24]=1>>[CH3:1][O:2][C:3]([C:5]1[C:6](=[O:17])[S:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[C:10]([C:23]1[CH:22]=[CH:21][CH:20]=[C:19]([F:18])[CH:24]=1)[CH:9]=2)=[O:4]

Participants

3

Reactant 2

HCID 27339863-Fluorophenylboronic acidHCID 178498916HCID 178498916, compound

Product 1

HCID 178498923HCID 178498923, compound

Procedure

7-(3-Fluoro-phenyl)-4-hydroxy-2-oxo-2H-thiochromene-3-carboxylic acid methyl ester was prepared from 7-bromo-4-hydroxy-2-oxo-2H-thiochromene-3-carboxylic acid methyl ester under conditions analogous to Example 7(a) using 3-fluorophenylboronic acid. 1H NMR (200 MHz, CDCl3): δ (ppm)=8.41 (d, 1H), 7.625-7.114 (m, 6H), 4.02 (s, 3H).

Sources & evidence

ORD record
ord-474d3eaba1a947a490bdb0be97c7bb4f
Source dataset
uspto-grants-2015_10
Patent number
US09149476B2

Reaction notes

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