2-Chlorophenylboronic acid → HCID 178498910, compound

HRID 1746218Notes

Reaction equation

HRID 1746218 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:6](=[O:17])[S:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][C:11](Br)=[CH:10][CH:9]=2)=[O:4].[Cl:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1B(O)O>>[CH3:1][O:2][C:3]([C:5]1[C:6](=[O:17])[S:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][C:11]([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=1[Cl:18])=[CH:10][CH:9]=2)=[O:4]

Participants

3

Reactant 2

HCID 27343222-Chlorophenylboronic acidHCID 178498908HCID 178498908, compound

Product 1

HCID 178498910HCID 178498910, compound

Procedure

6-(2-Chloro-phenyl)-4-hydroxy-2-oxo-2H-thiochromene-3-carboxylic acid methyl ester was prepared from 6-bromo-4-hydroxy-2-oxo-2H-thiochromene-3-carboxylic acid methyl ester under conditions analogous to Example 7(a) using 2-chloro-phenylboronic acid. 1H NMR (200 MHz, CDCl3): δ (ppm)=8.412 (s, 1H), 7.697 (d, 1H), 7.490-7.305 (m, 5H), 4.018 (s, 3H).

Sources & evidence

ORD record
ord-c5a5051f29d24021a7296debfaf3f15e
Source dataset
uspto-grants-2015_10
Patent number
US09149476B2

Reaction notes

Loading…