HCID 86718990, compound → HCID 86718991, compound

Participants

Reaction Steps

To 4-(4-(2-(2-(prop-2-ynyloxy)ethoxy)ethoxy)phenyl)-1,2,4-triazolidine-3,5-dione (I-7d: 153 mg, 0.479 mmol) in CH2Cl2 (4.792 mL) was added SiO2-HNO3 (300 mg). The mixture was stirred at room temperature for 15 minutes, then filtered, concentrated in vacuo and dried giving 4-(4-(2-(2-(prop-2-ynyloxy)ethoxy)ethoxy)phenyl)-3H-1,2,4-triazole-3,5(4H)-dione (112 mg, 74%) as a red oil. 1H NMR (400 MHz, CD3CN) δ ppm 2.60 (t, J=2.40 Hz, 1 H) 3.44-3.62 (m, 4 H) 3.68-3.75 (m, 2 H) 4.02-4.12 (m, 4 H) 7.02 (d, J=9.09 Hz, 2 H) 7.23 (d, J=8.84 Hz, 2 H).

Provenance & Evidence