HCID 71230594, compound → HCID 71230585, compound

HRID 1746273Notes

Reaction equation

HRID 1746273 reaction equation
[O:1]=[C:2]1[N:6]([CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12](=[O:18])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15])[C:5](=[O:19])[NH:4][NH:3]1>C(Cl)Cl>[O:1]=[C:2]1[N:6]([CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12](=[O:18])[O:13][C:14]([CH3:15])([CH3:16])[CH3:17])[C:5](=[O:19])[N:4]=[N:3]1

Participants

3

Reactant 1

HCID 71230594HCID 71230594, compound

Product 1

HCID 71230585HCID 71230585, compoundYield 100.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To tert-butyl 4-(3,5-dioxo-1,2,4-triazolidin-4-yl)butylcarbamate (15 mg, 0.055 mmol) in CH2Cl2 (0.551 mL) was added SiO2—HNO3 (35 mg). The mixture was stirred at room temperature for 15 minutes, then filtered, concentrated in vacuo and dried, giving tert-butyl 4-(3,5-dioxo-3H-1,2,4-triazol-4(5H)-yl)butylcarbamate (I-8c: 15 mg, quantitative yield) as a red oil.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated in vacuo
  3. customdried

Sources & evidence

ORD record
ord-34bbf236d8dd44e88527afdd3f1e4d10
Source dataset
uspto-grants-2015_10
Patent number
US09149541B2

Reaction notes

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