HCID 71230561, compound → HCID 71230590, compound

Participants

Reaction Steps

To benzyl 4-(3,5-dioxo-1,2,4-triazolidin-4-yl)butylcarbamate (I-9b: 369 mg, 1.205 mmol) in methanol (4.819 mL) was added 10% Pd/C (51.3 mg, 0.048 mmol). The mixture was stirred at room temperature for 1 hour under 1 atm of H2, filtered over celite, rinsed with more methanol, concentrated in vacuo and dried to give 4-(4-aminobutyl)-1,2,4-triazolidine-3,5-dione (I-9c: 105 mg, 51%) as a white solid. 1H NMR (400 MHz, MeOD) δ ppm 1.51-1.79 (m, 4 H) 2.94 (t, J=7.20 Hz, 2 H) 3.50 (t, J=6.57 Hz, 2 H).

Provenance & Evidence