N-(Methoxycarbonyl)maleimide → HCID 71230565, compound

Participants

Reaction Conditions

Reaction Steps

To 4-(4-aminobutyl)-1,2,4-triazolidine-3,5-dione hydrochloride (I-14a: 42 mg, 0.201 mmol) in NaHCO3 sat aqueous solution (1.006 mL) at 0° C. was added N-methoxycarbonylmaleimide (31.2 mg, 0.201 mmol). The mixture was stirred at 0° C. for 1 h, and then at room temperature for 2 h. The mixture was purified by preparative hplc (0-60% CH3CN/(0.1% TFA in H2O)), and then lyophilized, giving 4-(4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)butyl)-1,2,4-triazolidine-3,5-dione (I-14b: 10 mg, 20%) a white solid. LC-MS (M+1) 253.3, t=0.89 minute. 1H NMR (400 MHz, CD3CN) δ ppm 1.51-1.62 (m, 4H) 3.45 (t, J=6.44 Hz, 2H) 3.49 (t, J=6.44 Hz, 2 H) 6.76 (s, 2 H) 7.52 (br. s., 2 H).

Provenance & Evidence