Trimethylsilylacetylene → 6-iodo-2-[4-(4-trimethylsilyl-1H-1,2,3,-triazole-1-yl)phenyl]imidazo[1,2-a]pyridine

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Reaction Steps

Then, 6-iodo-2-(4-azidophenyl)imidazo[1,2-a]pyridine as prepared above is allowed to react with trimethylsilyl acetylene to obtain 6-iodo-2-[4-(4-trimethylsilyl-1H-1,2,3,-triazole-1-yl)phenyl]imidazo[1,2-a]pyridine (FIG. 1, step 2) in accordance with known methods (for example, the method described in a literature, James T. Fletcher et al., Tetrahedron Lett, 2008, 49, p. 7030-7032), and then trimethylsilyl group is removed (FIG. 1, step 3), to obtain 6-iodo-2-[4-(1H-1,2,3,-triazole-1-yl)phenyl]imidazo[1,2-a]pyridine.

Provenance & Evidence