2-Pyridinamine, 5-iodo- → HCID 71079854, compound

Participants

Reaction Steps

120 mg (corresponding to 0.454 mmol) of 4-(1H-pyrrole-1-yl)phenacylbromide and 99.9 mg (corresponding to 0.454 mmol) of 2-amino-5-iodopyridine were dissolved in 2.0 mL of acetonitrile. The resulting solution was heated under reflux for 2 hours. After the completion of the reaction, the reaction solution was cooled down to room temperature, and precipitates were filtered. The precipitates were washed with acetonitrile and dried under reduced pressure. The resulting crude crystals were suspended in a mixed solution of 10 mL of water and 10 mL of methanol. Then, about 20 mL of a saturated sodium hydrogencarbonate solution was added thereto, and the mixture was sonicated for 20 minutes using an ultrasonic washing machine. Precipitates were filtered and recovered from the resulting mixture, sufficiently washed with water, and dried under reduced pressure, to obtain 120 mg (corresponding to 0.312 mmol) of 6-iodo-2-[4-(1H-pyrrole-1-yl)phenyl]imidazo[1,2-a]pyridine (FIG. 2, step 2).

Provenance & Evidence