HuagongsheHuagongshe Chemistry Print Report · For research reference only
Z-O-tert-butyl-L-serine N-hydroxysuccinimide ester → HCID 178423965, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Z-O-tert-butyl-L-serine N-hydroxysuccinimide ester | HCID 2729196 | — |
| Reactant | Purine, 6-bromo- | HCID 5287830 | — |
| Reactant | 2-Amino-6-bromopurine | HCID 6101139 | — |
| Reactant | (2,5-Dioxopyrrolidin-1-yl) 2-(phenylmethoxycarbonylamino)butanoate | HCID 12961228 | — |
| Reactant | HCID 178423963 | HCID 178423963 | — |
| Reactant | HCID 178456854 | HCID 178456854 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | HCID 178423965 | HCID 178423965 | — |
Reaction Steps
Compound 68 was prepared using the general procedure described above with respect to compound 14, but 2-benzyloxycarbonylamino-3-tert-butoxy-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester was substituted for 2-benzyloxycarbonylaminobutyric acid 2,5-dioxo-pyrrolidin-1-yl ester in step B, and 2-amino-6-bromopurine was substituted for 6-bromopurine in step D. The obtained 2-[1-(2-amino-9H-purin-6-ylamino)-2-tert-butoxy-ethyl]-5-methyl-3-phenyl-3H-quinazolin-4-one was then dissolved in trifluoroacetic acid and allowed to stir at ambient temperature for 5 hours. Purification by LC provided the product 68 as a white solid. MS (ES): m/z 429 (M+H), 215, 206, 151. Compound 68 is shown below.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09149477B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-0cd03cdbc17f480da66b62c1e16b9c0a |
| Source note | uspto-grants-2015_10 |