HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(5-Methyl-4-oxo-2-(1-[9-(2-trimethylsilylethoxymethyl)-9H-purin-6-ylamino]ethyl)-4H-quinazolin-3-yl)benzamide → 3-{5-Methyl-4-oxo-2-{l-[9H-purin-6-ylamino)-ethyl]-4H-quinazolin-3-yl}-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(5-Methyl-4-oxo-2-(1-[9-(2-trimethylsilylethoxymethyl)-9H-purin-6-ylamino]ethyl)-4H-quinazolin-3-yl)benzamide | HCID 66663949 | — |
| Reactant | 3-(3-hydroxy-phenyl)-5-methyl-2-[1-(9H-purin-6-ylamino)-ethyl]-3H-quinazolin-4-one | HCID 178423955 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-{5-Methyl-4-oxo-2-{l-[9H-purin-6-ylamino)-ethyl]-4H-quinazolin-3-yl}-benzamide | HCID 178423954 | — |
Reaction Steps
Compound 143 was treated with 4N HCL in MeOH for 1.5 hours using the procedure described for compound 121 (step D) to provide compound 142. m/z=441 (M+H). The structure of compound 0.142 is shown below.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09149477B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-f893a73b74f74363930ce1171a942c2f |
| Source note | uspto-grants-2015_10 |