Methanol → methyl (2R)-2-amino-3-phenylpropanoate;hydrochloride

Participants

Reaction Conditions

Reaction Steps

To a chilled solution of methanol (1000 ml), was charged thionyl chloride (100 ml, 1.361 moles) at 5° C.±3° C. under nitrogen atmosphere. D-Phenyl alanine (100 grams, 0.602 moles) was added at 5° C.±3° C. and further stirred for 30 minutes. The temperature was raised to 25° C. The reaction mass was further stirred for 12 hours and concentrated at 50° C. under reduced pressure to form a residue. The residue was stirred in toluene (500 ml). The solid was isolated by filtration, washed with toluene (2×500 ml) and dried at 50-55° C. under vacuum to yield the desired product.

Provenance & Evidence