Ammonia → methyl (2R)-2-amino-3-phenylpropanoate;hydrochloride

Participants

Reaction Conditions

Reaction Steps

To a chilled solution of methanol (500 ml), was charged thionyl Chloride (50 ml, 0.681 moles) at 5° C.±3° C. under nitrogen atmosphere. D-Phenyl alanine (50 grams, 0.301 moles) was added at 5° C.±3° C. and further stirred for 30 minutes. The temperature was raised to 25° C. The reaction mass was further stirred for 12 hours and concentrated at 50° C. under reduced pressure to obtain residue. Basified with aqueous ammonia, extracted with dichloromethane (250 ml×2), dried over sodium sulphate and concentrated to obtain D-phenyl alanine methyl ester hydrochloride.

Provenance & Evidence