Hydrochloric Acid → methyl (2R)-2-amino-3-phenylpropanoate;hydrochloride

Participants

Reaction Conditions

Reaction Steps

To a 20% solution of ethanolic HCl (75 ml), was charged D-Phenyl alanine (15 grams, 0.090 moles). The reaction mass was further stirred for 48 to 50 hours at 25-30° C. (the reaction does not go to completion, shows 10-12% of unreacted D-Phenyl alanine) and concentrated at 50° C. under reduced pressure to form the residue. The residue was stirred in toluene (100 ml). The solid was isolated by filtration, washed with toluene (2×25 ml) and dried at 50-55° C. under vacuum to yield the desired product.

Provenance & Evidence