Ethanol → HCID 57523007, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of cyclic epoxy ester 14 (107 mg, 0.5 mmol) in DMF/EtOH/H2O (1:1:0.5 mL) were added NH4Cl (160.5 g, 3 mmol) and NaN3 (197.4 g, 3 mmol) at 0° C. The mixture was then stirred at 25° C. for 10 h. After completion of reaction (monitored by TLC), EtOH was removed by rotary evaporation. The remaining solution was extracted with EtOAc (100 mL×3). The combined organic layers were washed with, brine (20 mL×6) and dried (Na2SO4). After evaporation of the solvent, the residue was purified by chromatography (petroleum ether/ethyl acetate (7/3 v/v) to obtain compound 15.

Provenance & Evidence