Hydrochloric Acid → HCID 86673201, compound

Participants

Reaction Steps

tert-Butyl (2-((2-((4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenamido)ethyl)amino)-2-oxoethyl)(methyl)carbamate was taken up in 2 mL of EtOAc and 2 mL of saturated HCl in EtOAc was added. The resulting reaction mixture was stirred at room temperature for 2 h. Enough saturated aqueous Na2CO3 was added to adjust the pH=8. The aqueous layer was extracted with EtOAc. The combined organic layers were washed with brine, dried (Na2SO4) and concentrated under reduced pressure to afford 530 mg of (4Z,7Z,10Z,13Z,16Z,19Z)—N-(2-(2-(methylamino)acetamido)ethyl)docosa-4,7,10,13,16,19-hexaenamide (99% yield).

Provenance & Evidence