HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminobenzyl alcohol → HCID 70926492, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminobenzyl alcohol | HCID 69331 | — |
| Reactant | Doconexent | HCID 445580 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Ammonium Chloride | HCID 25517 | — |
| Product | HCID 70926492 | HCID 70926492 | — |
Reaction Steps
(4-Aminophenyl)methanol (1 mmol) was taken up in 15 mL of CH2Cl2 along with (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoic acid (1 mmol) and HATU (1.1 mmol). The resulting reaction mixture was stirred at room temperature for 6 h and diluted with saturated aqueous NH4Cl. The two layers were separated and the organic layer was washed with brine, dried (Na2SO4) and concentrated under reduced pressure. Purification by silica gel chromatography (95% CH2Cl2, 5% MeOH) afforded (4Z,7Z,10Z,13Z,16Z,19Z)—N-(4-(hydroxymethyl)phenyl)docosa-4,7,10,13,16,19-hexaenamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09150504B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-809f626d763d4a11afb5de2678cb55ac |
| Source note | uspto-grants-2015_10 |