Lithium borohydride → HCID 86731583, compound

Participants

Reaction Steps

Methyl 3-(N-(2,4-dimethylphenyl)-N-isobutylsulfamoyl)benzoate (400 mg, 1.065 mmol) was dissolved in tetrahydrofuran (THF) (10 mL). To this solution was added lithium borohydride (2M in THF) (0.932 mL, 1.864 mmol). The reaction was left to stir overnight, at room temperature, overnight. The reaction was quenched by the addition of 5% citric acid (10 mL), and the reaction allowed to stir, under nitrogen for 1 hour. The reaction mixture was then diluted with ethyl acetate (25 mL), and the product extracted to the organic phase. The organic phase was dried by passing it through a hydrophobic frit, and then concentrated in vacuo to give the desired product, N-(2,4-dimethylphenyl)-3-(hydroxymethyl)-N-isobutylbenzenesulfonamide, 378.7 mg.

Provenance & Evidence