Methyl 3-[4-(chlorosulfonyl)phenyl]propanoate → HCID 86731595, compound

HRID 1746423Notes

Reaction equation

HRID 1746423 reaction equation
[CH3:1][CH:2]([CH3:16])[CH2:3][NH:4][C:5]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:6]=1[CH3:15].Cl[S:18]([C:21]1[CH:26]=[CH:25][C:24]([CH2:27][CH2:28][C:29]([O:31][CH3:32])=[O:30])=[CH:23][CH:22]=1)(=[O:20])=[O:19]>N1C=CC=CC=1>[CH3:1][CH:2]([CH3:16])[CH2:3][N:4]([C:5]1[CH:10]=[C:9]([C:11]([F:12])([F:13])[F:14])[CH:8]=[CH:7][C:6]=1[CH3:15])[S:18]([C:21]1[CH:22]=[CH:23][C:24]([CH2:27][CH2:28][C:29]([O:31][CH3:32])=[O:30])=[CH:25][CH:26]=1)(=[O:20])=[O:19]

Participants

4

Reactant 2

HCID 23158517Methyl 3-[4-(chlorosulfonyl)phenyl]propanoateHCID 66478761HCID 66478761, compound

Product 1

HCID 86731595HCID 86731595, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of (2-methylpropyl)[2-methyl-5-(trifluoromethyl)phenyl]amine (50 mg, 0.216 mmol) in pyridine (5 mL) was added methyl 3-[4-(chlorosulfonyl)phenyl]propanoate (56.8 mg, 0.216 mmol). The mixture was stirred for 30 minutes to ensure dilution, then stood at room temperature, in air, for 16 hours. The solvent was evaporated in vacuo to give the crude product which was purified by MDAP (Method F) to give the required product, 21.5 mg. LCMS (M+1) 458, RT 1.39 mins.

Workup

  1. waitstood at room temperature, in air, for 16 hours
  2. customThe solvent was evaporated in vacuo
  3. customto give the crude product which
  4. customwas purified by MDAP (Method F)

Sources & evidence

ORD record
ord-53fd8e379086453e8a7eb1e42ac58793
Source dataset
uspto-grants-2015_10
Patent number
US09150508B2

Reaction notes

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