5-Chlorosulphonyl-2-anisic acid → HCID 71543456, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (2,4-dimethylphenyl)(2-methylpropyl)amine (200 mg, 1.128 mmol) in pyridine (3 mL) was added 5-(chlorosulfonyl)-2-methoxybenzoic acid (283 mg, 1.128 mmol) and the reaction stirred at 20° C. for 4 hours. The solvent was removed in vacuo and the crude purified by flash silica (Si) chromatography (using a 0-100%, ethyl acetate-dichloromethane gradient, with extra 0-20% methanol added). The appropriate fractions were combined and evaporated in vacuo to give the required product, 108 mg. LCMS (M+1) 392, RT 1.18 mins.

Provenance & Evidence