Sodium Acetate → HCID 71291709, compound

Participants

Reaction Steps

To a stirred solution of alcohol 1 (0.07 g, 0.18 mmol) in ethanol (10 mL) were added sodium acetate (10 mg, 0.12 mmol) followed by addition of 10% Pd/C (60 mg) at RT under inert atmosphere. The reaction mixture was stirred at RT for 2 h under H2 atmosphere (30 psi). Progress of reaction was monitored by TLC. The reaction mixture was filtered through a pad of celite and celite bed was washed with ethanol (2×10 mL). The filtrate was concentrated under reduced pressure to afford 2 (50 mg, 0.15 mmol, 78%) as a white solid. 1H NMR (500 MHz, CDCl3): δ 8.75 (s, 1H), 7.88 (s, 1H), 7.85 (s, 1H), 7.65 (d, J=8.5 Hz, 1H), 7.41 (d, J=8.5 Hz, 1H), 7.13 (s, 1H), 7.09 (s, 1H), 3.99 (s, 6H), 2.84-2.78 (m, 1H), 1.06 (d, J=6.5 Hz, 3H), 0.87 (d, J=6.5 Hz, 3H). Mass: m/z: 344 [M+1]. HPLC: 99.65%.

Provenance & Evidence