HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Methyl Nalpha-[3-(3-Acetoxyphenyl)acryloyl]-L-Tryptophanate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Propenoic acid, 3-[3-(acetyloxy)phenyl]- | HCID 140679 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | Methyl tryptophanate hydrochloride | HCID 2734891 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl Nalpha-[3-(3-Acetoxyphenyl)acryloyl]-L-Tryptophanate | HCID 86655438 | 98.2% |
Reaction Steps
The same procedures as in Example 2 were carried out from methyl L-tryptophanate hydrochloride (3.0 g), triethylamine (2.0 mL), 3-acetoxycinnamic acid (2.9 g), WSC.HCl (2.7 g), and methylene chloride (80 mL), to give the captioned compound (4.7 g, 98%) as an amorphous solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09150510B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-cc8dbd6f901f40cfb8ddccfb59bc19f8 |
| Source note | uspto-grants-2015_10 |