反应详情

Thionyl chloride (16.7 mL) was added dropwise to methanol (150 mL) at 0° C., and thereafter 1-methyl-L-tryptophanate (10.0 g) was added at room temperature. The mixture was allowed to stir for 20 hours, and thereafter heated and refluxed for 6 hours. To the residue obtained by distilling off the solvent under a reduced pressure was added diethylether, and crystals precipitated were filtered, to give the captioned compound (10.7 g, 87%).

1. temperatureheated
2. temperaturerefluxed for 6 hours
3. customTo the residue obtained
4. distillationby distilling off the solvent under a reduced pressure
5. additionwas added diethylether, and crystals
6. customprecipitated
7. filtrationwere filtered