HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Methyl Nalpha-[3-(2-Acetoxyphenyl)acryloyl]-1-Methyl-L-Tryptophanate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-(2-Acetoxyphenyl)-2-propenoic Acid | HCID 41486 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | methyl (2S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoate hydrochloride | HCID 67130420 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl Nalpha-[3-(2-Acetoxyphenyl)acryloyl]-1-Methyl-L-Tryptophanate | HCID 86655453 | 83.1% |
Reaction Steps
The same procedures as in Example 2 were carried out from the compound obtained in Example 20 (3.0 g), triethylamine (1.7 mL), 2-acetoxycinnamic acid (2.5 g), WSC.HCl (2.4 g), and methylene chloride (80 mL), to give the captioned compound (3.9 g, 83%) as an oily product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09150510B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-0736aacb88784a93915d3eb28b8e9454 |
| Source note | uspto-grants-2015_10 |