HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Methyl Nalpha-[3-(2,6-Difluorophenyl)acryloyl]-1-Methyl-L-Tryptophanate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (2E)-3-(2,6-difluorophenyl)acrylic acid | HCID 517784 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | methyl (2S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoate hydrochloride | HCID 67130420 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl Nalpha-[3-(2,6-Difluorophenyl)acryloyl]-1-Methyl-L-Tryptophanate | HCID 86655456 | 53% |
Reaction Steps
The same procedures as in Example 2 were carried out from the compound obtained in Example 20 (1.4 g), triethylamine (0,72 mL), 2,6-difluorocinnamic acid (1.0 g), WSC.HCl (1.0 g), and methylene chloride (50 mL), to give the captioned compound (1.1 g, 51%) as an oily product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09150510B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-e973d77034074aed8026d5842a74f9d0 |
| Source note | uspto-grants-2015_10 |