HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Methyl 1-Methyl-Nalpha-[3-(4-Phenoxyphenyl)acryloyl]-L-Tryptophanate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 4-Phenoxycinnamic acid | HCID 20992388 | — |
| Reactant | methyl (2S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoate hydrochloride | HCID 67130420 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 1-Methyl-Nalpha-[3-(4-Phenoxyphenyl)acryloyl]-L-Tryptophanate | HCID 86655459 | 55% |
Reaction Steps
The same procedures as in Example 2 were carried out from the compound obtained in Example 20 (1.0 g), triethylamine (0.54 mL), 4-phenoxycinnamic acid (0.94 g), WSC.HCl (0.75 g), and methylene chloride (40 mL), to give the captioned compound (0.93 g, 55%) as an oily product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09150510B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-9bfabcbe7dd8410fb13ec4ecc611b36f |
| Source note | uspto-grants-2015_10 |