1,4-Dioxane hydrochloride → HCID 67134472, compound

HRID 1746503Notes

Reaction equation

HRID 1746503 reaction equation
C(OC([NH:8][C@H:9]([C:22]([O:24][CH3:25])=[O:23])[CH2:10][C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]([CH:20]=[O:21])[CH:12]=1)=O)(C)(C)C.[ClH:26].O1CCOCC1>C(Cl)Cl>[ClH:26].[CH:20]([N:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:11]([CH2:10][C@@H:9]([C:22]([O:24][CH3:25])=[O:23])[NH2:8])=[CH:12]1)=[O:21]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86655460HCID 86655460, compound

Product 1

HCID 67134472HCID 67134472, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To methylene chloride (200 mL) solution of the compound obtained in Example 28 (8.9 g, 25.7 mmol) was added dropwise 4 mol/L of hydrogen chloride-dioxane (19 mL) at room temperature, and the mixture was allowed to stir for 15 hours. The crystals precipitated were filtered, and washed with diethyl ether, to give the captioned compound (7.2 g, 99%).

Workup

  1. customThe crystals precipitated
  2. filtrationwere filtered
  3. washwashed with diethyl ether

Sources & evidence

ORD record
ord-b9ebc7c43ed14c538283ee15c31cce4e
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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