HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-2-Tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionic acid methyl ester → (S)-Methyl 2-amino-3-(4-methoxyphenyl)propanoate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-2-Tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionic acid methyl ester | HCID 11220582 | — |
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (S)-Methyl 2-amino-3-(4-methoxyphenyl)propanoate hydrochloride | HCID 69612215 | 84% |
Reaction Steps
The same procedures as in Example 29 were carried out from the compound obtained in Example 32 (50.6 g), 4 mol/L of hydrogen chloride-dioxane (123 mL), and methylene chloride (400 mL), to give the captioned compound (33.7 g, 84%) as crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09150510B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-e62a68b7ae194205b45c6adc47a286b6 |
| Source note | uspto-grants-2015_10 |