HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Methyl N-[3-(2,6-Difluorophenyl)acryloyl]-O4-Methyl-L-Tyrosinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (2E)-3-(2,6-difluorophenyl)acrylic acid | HCID 517784 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | (S)-Methyl 2-amino-3-(4-methoxyphenyl)propanoate hydrochloride | HCID 69612215 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl N-[3-(2,6-Difluorophenyl)acryloyl]-O4-Methyl-L-Tyrosinate | HCID 86655474 | 82% |
Reaction Steps
The same procedures as in Example 2 were carried out from the compound obtained in Example 33 (2.5 g), triethylamine (1.7 mL), 2,6-difluorocinnamic acid (2.2 g), WSC.HCl (2.3 g), and methylene chloride (70 mL), to give the captioned compound (3.1 g, 82%) as crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09150510B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-1c19e8856df6429bbb2dd65d6764c8db |
| Source note | uspto-grants-2015_10 |