Sodium Hydroxide → HCID 86655483, compound

HRID 1746529Notes

Reaction equation

HRID 1746529 reaction equation
[C:1]([NH:5][C@H:6]([C:17]([O:19]C)=[O:18])[CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][CH:9]=1)(=[O:4])[CH:2]=[CH2:3].[OH-].[Na+:22]>CO>[C:1]([NH:5][C@H:6]([C:17]([O-:19])=[O:18])[CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][CH:9]=1)(=[O:4])[CH:2]=[CH2:3].[Na+:22]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86655436HCID 86655436, compound

Product 1

HCID 86655483HCID 86655483, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To methanol (50 mL) solution of the compound obtained in Example 1 (1.0 g, 3.7 mmol) was added I mol/L of an aqueous sodium hydroxide solution (5.6 mL) at room temperature. The mixture was allowed to stir for 2 hours, and thereafter to the residue obtained by distilling off the solvent under reduced pressure was added water, and the pH of the solution was adjusted to about pH 7 with polystyrene bound type p-toluensulfonate beads (2.8 mmol/g) (2.0 g), Beads were filtered off with a Millipore filter, thereafter the filtrate was distilled off under a reduced pressure, and the crystals precipitated were filtered with diethyl ether, to give the captioned compound (0.9 g, 87%).

Workup

  1. customto the residue obtained
  2. distillationby distilling off the solvent under reduced pressure
  3. additionwas added water
  4. filtrationwere filtered off with a Millipore
  5. filtrationfilter
  6. distillationthe filtrate was distilled off under a reduced pressure
  7. customthe crystals precipitated
  8. filtrationwere filtered with diethyl ether

Sources & evidence

ORD record
ord-4052efc12c3740ba816372d3daaa8f2a
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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