Sodium Hydroxide → HCID 67130532, compound

HRID 1746533Notes

Reaction equation

HRID 1746533 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]=[CH:9][C:10]([NH:12][C@H:13]([C:24]([O:26]C)=[O:25])[CH2:14][C:15]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[NH:17][CH:16]=1)=[O:11].[OH-].[Na+]>CO>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]=[CH:9][C:10]([NH:12][C@H:13]([C:24]([OH:26])=[O:25])[CH2:14][C:15]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[NH:17][CH:16]=1)=[O:11]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86655440HCID 86655440, compound

Product 1

HCID 67130532HCID 67130532, compoundYield 79.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To methanol (290 mL) solution of the compound obtained in Example 5 (7.1 g) was added dropwise 1 mol/L of an aqueous sodium hydroxide solution (29 mL) at room temperature. The mixture was allowed to stir for 29 hours, and thereafter to the residue obtained by distilling off the solvent under a reduced pressure was added water. The solution was made acidic with dilute hydrochloric acid, and the crystals precipitated were filtered, to give the captioned compound (5.4 g, 79%).

Workup

  1. customto the residue obtained
  2. distillationby distilling off the solvent under a reduced pressure
  3. additionwas added water
  4. customthe crystals precipitated
  5. filtrationwere filtered

Sources & evidence

ORD record
ord-b0de048468f24fb19f692b5fb48f8e44
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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