Sodium Hydroxide → HCID 86655494, compound

HRID 1746543Notes

Reaction equation

HRID 1746543 reaction equation
[F:1][C:2]([F:34])([F:33])[C:3]1[CH:4]=[C:5]([CH:13]=[CH:14][C:15]([NH:17][C@H:18]([C:29]([O:31]C)=[O:30])[CH2:19][C:20]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[NH:22][CH:21]=2)=[O:16])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[OH-].[Na+]>CO>[F:11][C:9]([F:10])([F:12])[C:7]1[CH:6]=[C:5]([CH:13]=[CH:14][C:15]([NH:17][C@H:18]([C:29]([OH:31])=[O:30])[CH2:19][C:20]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[NH:22][CH:21]=2)=[O:16])[CH:4]=[C:3]([C:2]([F:34])([F:1])[F:33])[CH:8]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86655449HCID 86655449, compound

Product 1

HCID 86655494HCID 86655494, compoundYield 83.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The same procedures as in Example 64 were carried out from the compound obtained in Example 16 (2.6 g), 1 mol/L of an aqueous sodium hydroxide solution (8.0 mL), and methanol (80 mL), to give the captioned compound (2.1 g, 83%) as crystals.

Sources & evidence

ORD record
ord-692706cd94c948309749ecbe65236513
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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