HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → Nalpha-[3-(2,5-Difluorophenyl)acryloyl]-1-Methyl-L-Tryptophan
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl Nalpha-[3-(2,5-Difluorophenyl)acryloyl]-1-Methyl-L-Tryptophanate | HCID 86655458 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Nalpha-[3-(2,5-Difluorophenyl)acryloyl]-1-Methyl-L-Tryptophan | HCID 86655499 | 75.1% |
Reaction Steps
The same procedures as in Example 64 were carried out from the compound obtained in Example 26 (2.9 g), 1 mol/L of an aqueous sodium hydroxide solution (15.0 mL), and methanol (150 mL), to give the captioned compound (2.1 g, 74%) as crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09150510B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-56ca19becc95466bad2658ae7999c573 |
| Source note | uspto-grants-2015_10 |