Sodium Hydroxide → Sodium N-Acryloyl-O4-Methyl-L-Tyrosinate

HRID 1746556Notes

Reaction equation

HRID 1746556 reaction equation
[C:1]([NH:5][C@H:6]([C:16]([O:18]C)=[O:17])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=1)(=[O:4])[CH:2]=[CH2:3].[OH-].[Na+:21]>CO>[C:1]([NH:5][C@H:6]([C:16]([O-:18])=[O:17])[CH2:7][C:8]1[CH:9]=[CH:10][C:11]([O:14][CH3:15])=[CH:12][CH:13]=1)(=[O:4])[CH:2]=[CH2:3].[Na+:21]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86655463Methyl N-Acryloyl-O4-Methyl-L-Tyrosinate

Product 1

HCID 86655501Sodium N-Acryloyl-O4-Methyl-L-TyrosinateYield 97%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The same procedures as in Example 60 were carried out from the compound obtained in Example 34 (1.9 g), 1 mol/L of an aqueous sodium hydroxide solution (11 mL), and methanol (70 mL), to give the captioned compound (1.9 g, 97%) as crystals.

Sources & evidence

ORD record
ord-a6d8425d604d4ab58daff75e623fc325
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

Loading…