Sodium Hydroxide → N-[3-(3-Fluorophenyl)acryloyl]-O4-Methyl-L-Tyrosine

HRID 1746561Notes

Reaction equation

HRID 1746561 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]([NH:12][C@H:13]([C:23]([O:25]C)=[O:24])[CH2:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[O:11])[CH:5]=[CH:6][CH:7]=1.[OH-].[Na+]>CO>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]([NH:12][C@H:13]([C:23]([OH:25])=[O:24])[CH2:14][C:15]2[CH:16]=[CH:17][C:18]([O:21][CH3:22])=[CH:19][CH:20]=2)=[O:11])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86655468Methyl N-[3-(3-Fluorophenyl)acryloyl]-O4-Methyl-L-Tyrosinate

Product 1

HCID 86655507N-[3-(3-Fluorophenyl)acryloyl]-O4-Methyl-L-TyrosineYield 61%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The same procedures as in Example 90 were carried out from the compound obtained in Example 39 (2.9 g), 1 mol/L of an aqueous sodium hydroxide solution (12 mL), and methanol (120 mL), to give the captioned compound (1.7 g, 61%) as crystals.

Sources & evidence

ORD record
ord-ce41083ae6934bd2bcef96867a2c0188
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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